Amides with anti-platelet aggregation activity from Piper taiwanense Fitoterapia. 2007 Sep;78(6):414-9. doi: 10.1016/j.fitote.2007.04.009. Epub 2007 May 24. Authors Ih-Sheng Chen 1, Yu-Chang Chen, Chang-Hui Liao. Affiliation 1 Graduate Institute of ... Plant Extracts / administration & dosage
Bioassay-directed fractionation of an ethanolic extract of the galls of Sapindus mukorossi has resulted in the isolation of two new tirucallane-type triterpenoid saponins, sapinmusaponins Q (1) and R (2), along with three known oleanane-type triterpenoid saponins (3-5). Their structures were elucida …
Results: Of the main plants discussed in this review, which have antiplatelet activity, some include saffron, garlic, green tea, St. John's wort, ginger, ginkgo biloba, ginseng, and …
However, as hypothesised by many works, the plant phenolic secondary metabolites may inhibit platelet activating factor and thromboxane A 2 induced platelet aggregation, help in controlling conformational changes in receptor expression and suppressing calcium formation and mobilization in platelet (Chen et al., 1996).
The subclass of flavonoids is widely addressed for their protective effects on CVDs by inhibiting platelet aggregation. Plant-based food groups are known to be richer in such compounds than others. ... In vitro anti-platelet effects of simple plant-derived phenolic …
It was postulated that both plants may contain common active constituents that contribute to inhibiting blood coagulation and/or platelet aggregation. Eighteen compounds, which have …
ABSTRACT Rapanea melanophloeos (L.) Mez is a medicinal plant that is used by Zulu traditional healers to manage blood-clot related diseases.Various extracts (methanol, n- hexane, chloroform, ethyl acetate and water) prepared from the bark of R. melanophloeos were screened for phytochemicals, antioxidant, and anti-platelet ...
Consumption of plant-food-derived bioactives, particularly flavonoids, has shown antithrombotic, and cardiovascular protective effects due to its anti-platelet activity. Preclinical and clinical trials have proven that flavonoid-rich plant extracts are protective against the cardiac ailments through anti-platelet aggregation activity.
Many anti-thrombosis and anti-platelet aggregation drugs have been discovered and applied in treatment. However, these drugs have many side effects such as bleeding, stomach lesion, etc. Vietnam ...
The results showed an increased anti platelet effects of aspirin when consumed in conjunction with chocolate. The consumption of dark chocolate enriched with flavan-3-ol, but …
Aim of the study: In this work the endothelium-dependant vasorelaxant and anti-platelet aggregation activities of an aqueous extract from Ocimum basilicum were studied. Materials and methods: The vasorelaxant effect was undertaken in thoracic aorta from three experimental groups of rats: one of them (NCG) fed with standard diet, the second (HCG) with …
It was postulated that both plants may contain common active constituents that contribute to inhibiting blood coagulation and/or platelet aggregation. Eighteen compounds, which have been reported to be present in both plant medicines, were evaluated for their effects on platelet aggregation and blood coagulation.
The anti-platelet aggregation effects of the two medicines induced by arachidonic acid (AA) were investigated. Results: The chemical profiles of these two species of "Dragon's Blood" were significantly different. The characteristic constituents were found to be: flavanes in RDD and stilbenes in RDC. ... Plant Extracts / pharmacology*
Large randomized double-blind clinical trials are required to evaluate the anti-platelet characteristics of these plants for the adjuvant primary prevention of cardiovascular disease. …
Although some compounds isolated from this plant have anti-platelet aggregation effects, the main chemical components and mechanism of J. procumbens in terms of these effects are little known. Aims of the study: Through in vivo and in vitro experiments, this studsy revealed the characteristic components and action mechanism of anti-platelet ...
The subclass of flavonoids is widely addressed for their protective effects on CVDs by inhibiting platelet aggregation. Plant-based food groups are known to be richer in such compounds than others. ... In vitro anti-platelet effects of simple plant-derived phenolic compounds are only found at high, non-physiological concentrations. Molecular ...
Ginger is the rhizome of Zingiber officinale, a perennial plant in the family Zingiberaceae. It is consumed as delicacy, medicine, or spice. It is often pickled in vinegar or sherry as a snack or just cooked as an ingredient in many dishes. ... The anti-platelet aggregation results are summarized in Table 1. All the tested compounds displayed ...
The Quantitative Trait Loci Mapping of Rice Plant and the Components of Its Extract Confirmed the Anti-Inflammatory and Platelet Aggregation Effects In Vitro and In Vivo Antioxidants (Basel). 2021 Oct 26;10 (11):1691. ... and significantly reduced rat platelet aggregation induced by collagen treatment. Therefore, cq-9 presents research ...
Stago's platelet aggregometer can be used in the: Diagnosis of Platelet function disorders; Confirmation of HIT; Monitoring of anti-platelet drugs; Identification of Von Willibrand Disease via Ristocetin Induced Platelet Aggregation (RIPA) Stago offers six reagents for use on the TA Series aggregometer: Arachidonic Acid (Ref:86922) ADP (Ref: 86923)
Amyrin inhibits collagen-induced platelet aggregation (IC50 = 10.5 µM), inhibits acetylcholinesterase (IC50 = 165 µM), and has antifungal and hepatoprotective effects.{33536,33538,33539,33540} Extracts of certain plants, used in herbal medicine to treat inflammation, have been shown to contain ?-amyrin, suggesting that this compound ...
Anti-thrombotic Effects Mediated by a Novel Dual-Target Peptide Inhibiting Both Platelet Aggregation and Thrombin Activity without Causing Bleeding ... but only PTIP was capable of inhibiting platelet aggregation. PTIP (1.0 mg/kg) decelerated thrombosis formation in venous and arterial vessels induced by FeCl3 injury. PTIP (1.0 mg/kg) also ...
↓ Platelet aggregation (healthy donors); ↓ platelet aggregation (donors with cardiovascular disorders); no cytotoxicity effects on human blood platelets, mouse fibroblast cultures L929 and human lung cells A549 : A. ursinum and A. sativum extracts: Blood from healthy volunteers: ↓ Platelet aggregation via inhibition ADP pathway
The inhibitory activities of I and II against rat platelet aggregation were compared with that of aspirin, a known inhibitor of platelet aggregation. Discussions also included the results of the investigations on the structural activity relationships among the various dihydroxybenzoic acid derivatives against platelet aggregations induced by ...
Background: The current light transmission aggregation method is a recognized conventional method for platelet function evaluation, but it is time-consuming and poor in parallelism and cannot simultaneously monitor multiple inducers at multiple levels. The microtiter plate method has been established because of the high-throughput characteristic, but it needs more …
Platelet aggregation inhibitors work in different places of the clotting cascade and prevent platelet adhesion, therefore no clot formation. Aspirin, the most commonly used antiplatelet drug changes the balance between prostacyclin (which inhibits platelet aggregation) and thromboxane (that promotes aggregation). ...
Anti-platelet aggregation and chemical constituents from the rhizome of Gynura japonica Planta Med. 2003 Aug;69(8):757-64. doi: 10.1055/s-2003-42796. Authors Wei-Yu Lin 1 ... Plant Oils / pharmacology* Plant Oils / therapeutic use Platelet Aggregation / drug effects* ...
Osunsanmi, F. O., Oyinloye, B. E., Mosa, R. A., Ikhile, M. I., Ngila, J. C., Shode, F. O., … Opoku, A. R. (2016). Anti-platelet aggregation of mixtures of betulinic ...
Three anthraquinone glycosides were found to be platelet anti-aggregatory constituents of seeds of Cassia obtusifolia and their structure-activity relationships are discussed. Three anthraquinone glycosides, gluco-obtusifolin [11], gluco-chryso-obtusin [15], and gluco-aurantioobtusin [13], were found to be platelet anti-aggregatory constituents of seeds of …
Many anti-thrombosis and anti-platelet aggregation drugs have been discovered and applied in treatment. However, these drugs have many side effects such as bleeding, stomach lesion, etc. Vietnam is a tropical country with plenty of medicinal plants, from which a potential drug for anti-thrombolytic activities can be prepared. ... Therefore, an ...
Handbook of compounds with anti-inflammatory and anti-platelet aggregation activities isolated from plants ... Handbooks, Platelet Aggregation Inhibitors -- Handbooks, Plant Extracts -- isolation & purification -- Handbooks, Plants, Medicinal -- metabolism -- Handbooks ...